Myocardial T1 mapping and extracellular volume quantification: an overview of technical and biological confounders

Myocardial T1 and extracellular volume fraction mapping at 3 tesla

BACKGROUND To compare 11 heartbeat (HB) and 17 HB modified lock locker inversion recovery (MOLLI) pulse sequence at 3T and to establish preliminary reference values for myocardial T1 and the extracellular volume fraction (ECV). METHODS Both phantoms and normal volunteers were scanned at 3T using 11 HB and 17 HB MOLLI sequence with the following parameters: spatial resolution = 1.75 × 1.75 × 1...

Characterising the myocardial interstitial space: clinical relevance of T1 and extracellular volume mapping

Subclinical myocardial inflammation and diffuse fibrosis are common in systemic sclerosis – a clinical study using myocardial T1-mapping and extracellular volume quantification

BACKGROUND Systemic sclerosis (SSc) is characterised by multi-organ tissue fibrosis including the myocardium. Diffuse myocardial fibrosis can be detected non-invasively by T1 and extracellular volume (ECV) quantification, while focal myocardial inflammation and fibrosis may be detected by T2-weighted and late gadolinium enhancement (LGE), respectively, using cardiovascular magnetic resonance (C...

Regional left ventricular myocardial T1 and velocity mapping: elevated extracellular volume fraction is associated with altered myocardial velocities

Background Non-ischemic cardiomyopathy (NICM) is a common cause of left ventricular (LV) dysfunction and may be associated with myocardial fibrosis. Global LV systolic function may underestimate the impact of fibrosis on myocardial function and is insensitive to regional abnormalities in myocardial motion. Advances in cardiac MRI have enabled quantification of myocardial fibrosis through the ca...

T1 mapping for myocardial extracellular volume measurement by CMR: bolus only versus primed infusion technique.

OBJECTIVES The aim of this study was to determine the accuracy of the contrast "bolus only" T1 mapping cardiac magnetic resonance (CMR) technique for measuring myocardial extracellular volume fraction (ECV). BACKGROUND Myocardial ECV can be measured with T1 mapping before and after contrast agent if the contrast agent distribution between blood/myocardium is at equilibrium. Equilibrium distri...